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This Concept Map, created with IHMC CmapTools, has information related to: V13. Hereditary nonpolyposis colon cancer - HNPCC, Develop polyps leads to 80% lifetime risk of developing cancer, Develop other cancers namely Small bowell, Microsatellite Instability ie Insertions or deletions of repetitive units, Autosomal Dominant although it follows Two hit hypothesis, Early detection! can be detected Prenatally, 13. HEREDITARY NONPOLYPOSIS COLON CANCER (HNPCC) considered a Cancer Predispostion Syndrome, Cancer Predispostion Syndrome characterized by mutations in Mismatch Repair Genes, Each child has 45% of developing cancer ie. 50% chance of inheriting bad gene X 90% that the bad gene will cause cancer, Autosomal Dominant risk 50% if parent has it, Develop other cancers but not Lung, Mismatch Repair Genes usually in the following genes: MLH's, 13. HEREDITARY NONPOLYPOSIS COLON CANCER (HNPCC) phenotype Develop polyps, Early detection! methods Colonoscopy, Develop other cancers namely Endometrium/ ovarian, 13. HEREDITARY NONPOLYPOSIS COLON CANCER (HNPCC) phenotype Develop other cancers, Prenatally but Must know disease sequence, Develop other cancers namely Kidney, 13. HEREDITARY NONPOLYPOSIS COLON CANCER (HNPCC) inheritance Autosomal Dominant, Mismatch Repair Genes usually in the following genes: PMS, 13. HEREDITARY NONPOLYPOSIS COLON CANCER (HNPCC) statistics Accounts for 3-8% of colorectal cancer